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The results of the simulations are depicted in figure 21. In experiments A, B and C only the linear part of the stimulus-response characteristic is considered. In the graph, the crossing of the curves with the Y-axis represents the spontaneous activity of the system. 1 Figure 20. Stimulus response curve of the model afferent nerve. The slopes of the curves represent the sensitivity. The values for sensitivity and spontaneous activity of the 3 experiments are given in table 2. The entire tree with all synapses, as simulated in experiment A is the most sensitive (472 Hz/nA).

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Gating properties of INa in the spike generator. Spike frequency is depicted in gray, the INa h-gating in black. A low value of h means high inactivation. The strong stimulus prevents removal of the inactivation. This leads to a decrease in spike amplitude. 51 In order to test the effects of a reduced number of inputs on the sensitivity, we simulated 3 experiments with different geometrical parameters. The first experiment (A) is similar to the results we already showed, it represents the entire dendritic tree, with at every terminal a sinusoidal I-Clamp to simulate a synapse.

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